Sumalate® has 40% absorption. This high absorption is due to the chelation. Iron is surrounded by glycine and aspartic acid which are important amino acids in aiding in iron absorption into the enterocytes. Since absorption is increased, mucosal block is limited and hepcidin is less likely to be released and inhibit ferroportin, the channel which moves ferrous iron out of the enterocytes and into the bloodstream. Therefore, it can be said chelated metals increase expression of ferroportin. Because the iron is chelated, it participates less in chemical reactions such as those with absorption inhibitors. Sumalate® can also be absorbed in the proximal or distal duodenum due to its chelation and bioavailability, and therefore is not limited to the proximal duodenum like ferrous salts.
*Bioavailability ranges for irons can vary greatly and may depend on iron form, dose, dose regimen, and other ingredients in the product formulation. Representative bioavailability is dervied from published studies of the iron forms alone.